Sero-prevalence of hepatitis B and C and HIV among students at the Federal University of Health Sciences, Azare, Bauchi State
Main Article Content
Keywords
Seroprevalence Survey, Hepatitis, HBV , HCV, HIV, FUHSA
Abstract
Background: Infection with the human immunodeficiency virus and hepatitis viruses B and C have been reported to be endemic in some Nigeria’s institutions of higher learning. Several studies have reported varying prevalence rates for hepatitis B and C viruses and HIV among undergraduate students in Nigerian universities.
Methodology: A cross-sectional descriptive prevalence study of hepatitis B and C viruses and HIV among students at Federal University of Health Sciences, Azare conducted on the 2nd of December 2023. Screening for hepatitis B and C viruses and HIV was done using standard procedures. Ethical approval was obtained in addition to individual consent from all participants.
Results: Three hundred students with the mean age of 19.43±2.352 years were studied. 96.7% were aged 24 years or younger; females being the majority [185, 61.7%]. The majority of the participants were in their 200 level (190, 63.3%). Ten health-related programmes were represented in the survey. Twelve participants (4%) were positive for HBsAg; nine (75%) being males. One participant was positive for HBeAg, while only three (1%) of the participants had evidence of prior HBV vaccination, thus giving us a window of opportunity for vaccination. None of the participants had evidence of infection with HCV or HIV.
Conclusion: Screening students of health-related courses should be routinely done to ascertain their status to prevent occupational exposures and transmission in the healthcare setting. Results from this survey will inform formulation of policies that will protect our future healthcare force and safeguard the lives of patients.
References
2. Enitan SS, Adebola OK, Adejumo EN, Itodo GE, Ileoma E, Oluremi AS, Omotola D. Prevalence of Hepatitis B and C Virus Infection among Students of a Private Tertiary Institution in South-Western Nigeria. IJTDH. 2019; 36(3): 1-15.
3. Ojerinde OA, Ojo SKS, Udewena UL, Oladeji SJ. A cross-sectional study on the prevalence of HIV and hepatitis B virus co- infection among students of a tertiary institution in Ekiti State, Southwest Nigeria. Pan Afr Med J. 2023;44(7). 10.11604/pamj.2023.44.7.31416
4. Dawurung JS, Bukbuk DN, Ajayi BB, Baba MM. Prevalence of hepatitis B and C virus co-infection among students of University of Maiduguri, Nigeria. Arch. Appl. Sci. Res. 2012, 4 (4):1581-1584.
5. Chen DS. Toward elimination and eradication of hepatitis B. J. Gastroenterol. Hepatol. 2010; 25: 19–25.
6. https://www.who.int/news-room/fact-sheets/detail/hepatitis-b (accessed 6th June 2024)
7. https://www.hepb.org/assets/Uploads/Nigeria-Hepatitis-Guidelines-TX-guidelines.pdf
8. MacLachlan JH, Locarnini S, Cowie BC. Estimating the global prevalence of hepatitis B. Lancet. 2015 Oct 17;386(10003):1515–7.
9. Global health sector strategies on, respectively, HIV, viral hepatitis and sexually transmitted infections for the period 2022-2030. Geneva: World Health Organization. 2022. License: CC BY-NC-SA 3.0 IGO.
10. Shawa IT. Hepatitis B and C viruses. In: hepatitis B and C. Intech open; 2019. DOI: http://dx.doi.org/10.5772/intechopen.8 2772
11. Odemuyiwa SO, Mulders MN, Oyedele OI, Ola SO, Odaibo GN, Olaleye DO, et al. Phylogenetic analysis of new Hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa. J. Med. Virol. 2001; 65:463-469.
12. Musa BM, Bussell S, Borodo MM, Samaila AA, Femi OL. Prevalence of hepatitis B virus infection in Nigeria, 2000-2013: A systemic review and meta-analysis. Nig J Clin Pract. 2015; 18(2):163-172.
13. Isa I, Aminu M, Abdullahi SA, Sani MA, Esona MD. Seroprevalence of hepatitis B virus in a tertiary institution in North Western Nigeria. Afric J Microbiol Res. 2015;9(3): 171-9.
14. Alo MN, Alhassan HM, Saidu AY, Ugah UI, Abdullahi H. Seroprevalence of hepatitis B surface antigen (HBsAg) among the medical students of Usmanu Danfodiyo University, Sokoto, Sokoto State, Nigeria. Eur J Exp Biol. 2013;3(3): 666-671.
15. Tula MY, Iyoha O. A cross-sectional study on the seroprevalence of HBsAg among apparently healthy students of a tertiary institution in North-eastern Nigeria. Int J Trop Dis Health. 2015;7(3): 102-108.
16. Pennap GR, Nwachukwu O, Ishaleku D, Ombugadu RJ. Hepatitis B virus carriage among students of a Nigerian Tertiary Institution: a cohort of eligible blood donors. Res J Med. 2011;5: 903.
17. Olalekan AW. Prevalence and risk factors for hepatitis B and C among sexually active undergraduates in southwestern Nigeria. Ann Trop Med Public Health. 2015;8(6): 235-40.
18. Imarenezor EPK, Brown STC, Yakubu OE, Soken DC. Survey of Hepatitis B and C among students of Federal University Wukari, Taraba State, Nigeria. Int Res J Med Med Sci. 2016; 4(3): 31-37.
19. Udeze AO, Adeoye PA, Odugbes AE, Sule WF, Okonkwo IO. Hepatitis B and C seropositivity in a cohort of positive patients in Ilorin, north-central. Nig J Microbiol 2015;28:2767-2776.
20. Aminu M, Emanuel EO, Sani MA, Abdulateef Y. Prevalence of HBsAg among healthy asymptomatic students in a Nigerian university. Ann Afr Med. 2013 Jan-Mar;12(1):55-6.
21. Isa MA, Bello HS, MustaphaA, ManggaHK, GulaniIA, AishaMA. Prevalence of hepatitis B Virus among students attending University of Maiduguri clinic, Borno state. Nigeria. Int. J. Adv. Res. Biol. Sci. 2015;2(1):138–142.
22. Zampino R, Boemio A, Sagnelli C, Alessio L, Adinolfi LE, Sagnelli E, et al. Hepatitis B virus burden in developing countries. World J Gastroenterol. 2015 Nov 14;21(42):11941–53.
23. GBD 2019 Hepatitis B Collaborators. Global, regional, and national burden of hepatitis B, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Gastroenterol Hepatol. 2022 Sep;7(9):796-829.
24. Wang Y, Cheng J, Xu C, Liu S, Jiang S, Xu Q, et al. Quantitative methylation analysis reveals gender and age differences in p16INK4a hypermethylation in hepatitis B virus-related hepatocellular carcinoma. Liver Intern. 2012; 32(3):420–428.
25. Opare-Asamoah K, Majeed SF, AO Owusu, Keelson KO , Owusu EA, Wondoh PM, et al. The Prevalence and Risk Factors of Hepatitis B Virus Infection Among Dwellers in A Peri-Urban District of Ghana: A Cross-Sectional Study. Journ. of Med Biome. Sci (2021); 8(2): 12-20.
26. Mehmet D, Meliksah E, Serif Y, Gunay S, Tuncer O, Zeynep S. Prevalence of hepatitis B infection in the southeastern region of Turkey: comparison of risk factors for HBV infection in rural and urban areas. Jpn J Infect Dis. 2005;58(1): 15-9.
27. Akinbolaji TJ, Adekoya-Benson T, Akinseye FJ, Odeyemi FA, Adegeye FO, Ojo OI. Prevalence of Hepatitis B Virus and Hepatitis C Virus Co-Infections among Ekiti People in South-Western Nigeria. Intern. J Health Sci Res. 2015; 5(3): 121-6.
28. Lado ZY, Ogbaga CC, Nwagbara OF. Epidemiology of hepatitis B viral infection among students and non-teaching (casual) staff of Nile University of Nigeria: a 2017 study. J Pub Health Epidemiol. 2018;10(3): 77-86.
29. Simidele OM, Oladimeji A, Joseph AA, Aduayi V, Samuel NI. Burden of Hepatitis B Viral Infection among Workers in a Tertiary Health Institution in Southwestern Nigeria. Open Journ. Medical Micro. 2018;8(4): 85-97.
30. Leung J, Peacock A, Grebely J, Cunningham EB, Hickman M, et al. A Global Meta-analysis of the Prevalence of HIV, Hepatitis C Virus, and Hepatitis B Virus Among People Who Inject Drugs—Do Gender-Based Differences Vary by Country-Level Indicators? J Inf Dis 2019:220.
31. Mboto CI, Edet EJ. Prevalence and risk factors of hepatitis B virus infection among students in University of Uyo. Intern. J Mod. Bio Med. 2012;2(2): 101-111.
32. Ndako JA, Nwankiti OO, Echeonwu GO, Junaid SA, Anaele TJ, Anthony TJ. Studies on prevalence and risk factors for hepatitis B surface antigen among secondary school students in north-central Nigeria. S J Biomed Res. 2011;3(3): 163-168.
33. Uneke CJ, Ogbu PU, Anyanwu GI, Njoku MO, Idoko JH. Prevalence of hepatitis B surface antigen among blood donors and HIV-infected patients in Jos, Nigeria. Mem Inst Oswaldo Cruz. 2005;100(1): 13-16.
34. Kalra M, Mayes J, Assefa S, Kaul AK, Kaul R. Role of sex steroid receptors in pathobiology of hepatocellular carcinoma. World J.Gastroenterol. 2008; 14: 5945–61.
35. Ndako JA, Ojo S, Dojumo VT, Fajobi VO, Ifeanyi I, Akinwumi JA, et al. Sero-Epidemiological Analysis of Hepatitis B Virus Infection among Apparently Healthy Young Adults in Omuaran Community. Intern. J Pathogen Res. 2020;4(4): 31-38.
36. Wang SH, Chen, PJ and Yeh SH. Gender Disparity in Chronic Hepatitis B: Mechanisms of Sex Hormones. Journ. Gastroenterol Hepatology2015, 30, 1237-1245.
37. Liu Y. Gender differences in chronic hepatitis B virus infection: Immunological and clinical aspects. Journ. Clinical Immunology, 2017. 37(2), 118-125.
38. Baig S. Gender disparity in infections of Hepatitis B virus. J Coll Physicians Surg Pak. 2009 Sep;19(9):598-600.
39. Dinh TH, Hirai, T. Gender differences in hepatitis C virus infection: Epidemiology, clinical presentation, and treatment outcomes. Hepatology International, 2020; 14(3): 404-412.
40. Ojo O, Adebayo O, Afolabi MO. Prevalence of hepatitis C virus infection among undergraduates in a university in Southwestern Nigeria. Journ Infect. Dev Countries 2018; 12(3), 208-213.
41. Olusola BA, Akinyemi OA, Olorunfemi S. Prevalence and risk factors for hepatitis C virus infection among university students in Nigeria. Afri. J Infect. Dis.2020; 14(1), 49-55.
42. Okeke EN, Chijioke AA, Orji OF. Prevalence of hepatitis C virus among students in southeastern Nigeria. Nig. J Clinic. Pract, 2017; 20(3), 278-282.
43. Akinyemi AI. HIV prevalence and sexual risk behaviors among Nigerian university students. African. J Reprod Health, 2020; 24(2), 116-124.
44. Ogunbodede EO. Prevalence of HIV and associated risk factors among university students in southwestern Nigeria. J Infect. in Dev. Count, 2018; 12(6): 515-521.