Comparison Of Risk Factors and Clinicopathological Features Between Pre- and Post-Menopausal Patients with Breast Cancer
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Keywords
Breast Cancer, Pre-Menopausal, Post-Menopausal
Abstract
Background: Breast cancer is the most common cancer affecting women globally with an estimated 2.3 million new cases in 2020. In Nigeria, it constitutes about 12% of all new cancers and 25% of all cancers in women. The risk factors of breast cancer include both non-modifiable and modifiable factors. There are clinical and biological differences between patients with pre-menopausal and post-menopausal breast cancer. This study aims to evaluate the differences in risk factors, disease presentation and tumour characteristics between premenopausal and postmenopausal breast cancer patients.
Methodology: This is a 2-year prospective cross-sectional study conducted at the University of Port Harcourt Teaching Hospital between 1st January 2021 and 31st December 2022. All consecutive patients who presented with breast cancer that was histologically confirmed and gave informed consent were included in the study. Patients were divided into two groups which are pre-menopausal and post-menopausal based on their menopausal status. Relevant data were extracted and recorded in a data extraction form. Analysis was done using Statistical Product and Service Solution version 26.
Results: One hundred and thirty-three patients were recruited for the study. Seventy (52.6%) of them were pre-menopausal and 63 (47.4%) were post-menopausal. Their ages were from 19 to 78 with a mean of 46.94 ± 11.93. The peak age was 41-50 years and 30.8% of the patients were within this age range. Only late age at first pregnancy was significantly associated with pre-menopausal breast cancer.
Conclusion: Similar risk factors and tumour characteristics with a higher prevalence of triple-negative breast cancer were found in both groups but late age at first pregnancy occurred significantly in pre-menopausal breast cancer patients.
References
2. Wichendu PN, Dodiyi-Manuel A. Advanced breast cancer in Nigeria: A single centre experience. Afr J Biol Health Res 2021; 4: 51-56.
3. Henderson IC. Risk factors for breast cancer development. Cancer 1993; 71 (6 Suppl): 2127-2140.
4. Surakasula A, Nagarjunapu GC, Raghavaiah KV. A comparative study of pre-menopausal breast cancer: Risk factors, presentation, characteristics and management. J Res Pharm Pract 2014; 3: 12-18.
5. Dodiyi-Manuel A, Wakama IE. Predispositions of carcinoma of the breast: A review. Nig J Med 2014; 23: 7-12.
6. Kruk I. Lifetime physical activity and the risk of breast cancer: a case-controlled study. Cancer Detect Prev 2007; 31: 18-28.
7. Campbell KL, Foster Schubert KE, Alfano CM, Wang C, Wang C, Duggan CR, et al. Reduced calorie dietary weight loss, exercise and sex hormones in post-menopausal women: randomized controlled trial. J Clin Oncol 2012; 30: 2314-2326.
8. Kocaoz S, Korukluoglu B, Parlak O, Dogan HT, Erdogan F. Comparison of clinicopathological features and treatment between pre- and post-menopausal female breast cancer patients: a retrospective study. Menopause Rev 2019; 18: 1-6.
9. Gharaibeh M, Al-Obeisat S, Hattab J. Severity of menopausal symptoms of Jordanian women. Climacteric 2010; 13: 385-394.
10. Gao YT, Shu XO, Dai Q, Potter JD, Brinton LA, Wen W, et al. Association of menstrual and reproductive factors with breast cancer risk: results from the Shangai breast cancer study. Int J Epidemiol 2000; 87: 295-300.
11. Bao PP, Shu XO, Gao YT, Zheng Y, Cai H, Deming SL, et al. Association of hormone-related characteristics and breast cancer risk by estrogen/progesterone receptor status in the Shangai breast cancer study. Am J Epidemiol 2011; 174: 661-671.
12. Olaogun JG, Omotayo JA, Ige JT, Omonisi AE, Akute OO, Aduayi OS. Socio-demographic pattern of presentation and management outcome. PAMJ 2020; 36: 363.
13. Rahman GA, Olatoke SA, Agodirin SO, Adeniji KA. Socio-demographic and clinical profile of immuno-histochemically confirmed breast cancer in a resource-limited country. PAMJ 2014; 17: 182.
14. Nimbalkar VP, Rajarajan S, VP S, Alexander A, Kalure R, Selvam S, et al. A comparative analysis of clinicopathological features and survival between pre- and post-menopausal breast cancer from an Indian cohort. Sci Rep 2023; 13: 3938.
15. Pathy NB, Yip CH, Taib NA, Hartman M, Saxena N, Lau P, et al. Breast cancer in a multiethnic Asian setting: Results from the Singapore-Malaysia hospital-based breast cancer registry. Breast 2011; 20 (suppl 2): S75-S80.
16. Edge S, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A (editors). 7th ed. New York: Springer; 2010. AJCC Cancer Staging Manual; PP 347-369.
17. Butt Z, Haider SF, Arif S. A comparison between pre-menopausal and post-menopausal women. J Res Pharm. Pract 2014; 3: 12-18.
18. Zhang JY, Wang MX, Wang X, Li YL, Liang ZZ, Lin Y, et al. Association of reproductive factors with breast cancer prognosis and the modifying effects of menopausal status. Cancer Med 2020; 9:385-393.
19. Chie WC, Hsieh C, Newcomb PA, Longnecker MP, Mittendorf R, Greenberg ER, et al. Age at any full-term pregnancy and breast cancer risk. Am J Epidemiol 2000; 151: 715-722.
20. Kapil U, Bhodoria AS, Sareen N, Singh P, Dwivedi SN. Reproductive factors and risk of breast cancer: A review. Ind J Cancer 2014; 51: 571-576.
21. Bosompem K, Yorke J, Buckman TA, Brenu SG, Nyantakyi M, Somiah-Kwaw F, et al. Comparative analysis of breast cancer characteristics in young pre-menopausal and post-menopausal women in Ghana. Sci Rep 2024; 14: 2704.
22. Gukas ID, Jennings BA, Mandong BM, Igun GO, Girling AC, Manasseh AN, et al. Clinicopathological features and molecular markers of breast cancer in Jos, Nigeria. West Afr J Med 2005; 24: 209-213.
23. Dietze EC, Sistrunk C, Miranda-Carboni G, O’regan R, Seewaldt VL. Triple-negative breast cancer in African-American women: Disparities versus biology. Nat Rev Cancer 2015; 15: 248-254.
24. Nyagol J, Nyongo A, Byakika B, Muchiri L. Routine assessment of hormone receptor and her-2/neu status underscores the need for more therapeutic targets in Kenyan women with breast cancer. Anal Quant Cytol Histol 2006; 28: 97-103.
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