Sociodemographic and Economic Correlates of Dialysis Vintage in a Resource Challenged Setting: A Four-Year Prospective Study in Southwest Nigeria
Main Article Content
Keywords
Maintenance , Haemodialysis , Resource-challenged Settings , Dialysis Vintage , Mortality , Chronic Kidney Disease , Cardiovascular Function
Abstract
Background: Dialysis vintage is largely dependent on the effectiveness of the delivered dose coupled with the extent of patient compliance with the prescribed treatment regimen. This study assessed the determinants and correlates of dialysis vintage.
Methodology: This was a 4-year prospective, observational study. The data was collected from the dialysis and medical records, both had the contacts of patients and relatives.
Results: A total of 314 participants (males 67.20%) with a mean age of 47.91±8.81 years underwent 2265 maintenance haemodialysis sessions. The females were older and had more hospital admissions; (P=0.07). Approximately 32.17% of the participants traveled at least fifty kilometers to access dialysis treatment. In a month, only 23.57% of the participants received the minimum prescribed twelve sessions, and 24.84% received the required erythropoietin dose. The mean dialysis vintage for all population was 9.13 ± 3.15 months, it was shorter for participants with hospitalization, (p<0.001), dialysis termination (p<0.001), intradialytic hypotension (p<0.001), and hypertension (p<0.001), Approximately, 14.2% of the participants had health insurance coverage, more so with the men After dialysis initiation, 6.69% of the participants were alive to the fourth year. The predictors of dialysis vintage were income (OR-4.62, 95% CI-2.88-6.24), health insurance (OR-8.11, 95% CI-4.82-13.35), dialysis duration (OR-6.38, 95% CI-2.40-9.55) and spKt/V (OR-4.24, 95% CI-0.48-5.91).
Conclusion: Dialysis vintage was short (9.13 ± 3.15 months), more so in females, poor funding, peridialysis complications, and without health insurance. More concerted efforts from governments, multinational donor agencies, and philanthropists are needed in health insurance coverage, particularly for kidney care to increase the dialysis vintage.
References
2. Haller MC, Kammer M, Oberbauer R. Dialysis vintage and outcomes in renal transplantation. Nephrol Dial Transplant. 2019;34(4):555-560. doi: 10.1093/ndt/gfy099. PMID: 29897595.
3. Hariparshad S, Bhimma R, Nandlal L. Jembere E, Naiker S, Assounga A. The Prevalence of ChronicKidney in South Africa-limitations of Studies comparing Prevalence with sub-Saharan African, Africa, and Globally BMC Nephrology 2023; 24, 62 doi.org/10.1186s12882-023-03109-1
4. Kovesdy CP. Epidemiology of chronic kidney disease: an update 2022. Kidney Int Suppl (2011). 2022;12(1):7-11. doi: 10.1016/j.kisu.2021.11.003.
5. GBD Mortality Causes of Death Collaborators Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015; 385:117–171.
6. NBS. Nigeria multidimensional poverty index (2022). Abuja. Nigeria: National Bureau of Statistics; 2022.
7. Laos. From Wikipedia https://en.wikipedia.org/wiki/Laos
8. Okoye O, Mamven M. Global Dialysis Perspective: Nigeria. Kidney 360. 2022; 14;3(9):1607-1610. doi: 10.34067/KID.0002312022.
9. Akpan EE, Ekrikpo UE, Effa EE, Udo AIA, Umoh VA. Demographics, Cost, and Sustainability of Haemodialysis among End-Stage Kidney Disease Patients in Southern Nigeria: A Single-Center Study. Niger Med J. 2020; 61(6):307-311. doi: 10.4103/nmj.NMJ_106_20.
10. Agada-Amade YA, Ogbuabor DC, Eboreime E, Onwujekwe OE. Cost analysis of the management of end-stage renal disease patients in Abuja, Nigeria. Cost Eff Resour Alloc 2023; 21, 94. https://doi.org/10.1186/s12962-023-00502-3
11. Hanafusa N, Fukagawa M. Global Dialysis Perspective: Japan. Kidney360. 2020; 16;1(5):416-419. doi: 10.34067/KID.0000162020.
12. Toure AO, Balde MD, Diallo A, Camara S, Soumah AM, Sall AO, et al. The direct cost of dialysis supported by families for patients with chronic renal failure in Ouagadougou (Burkina Faso). BMC Nephrol. 2022;23(1):222. doi: 10.1186/s12882-022-02847-y.
13. Myanmar. From Wikipedia. https://en.wikipedia.org/wiki/Myanmar
14. Exantus J. Global Dialysis Perspective: Haiti. Kidney360. 2022;3(6):1105-1108. doi: 10.34067/KID.0007592021.
15. Ulasi I. Gender bias in access to healthcare in Nigeria: a study of end-stage renal disease. Trop. Doct. 2008; 38(1):50-2.
16.Arogundade FA, Barsoum RS. CKD prevention in Sub-Saharan Africa: a call for governmental, nongovernmental, and community support. Am J Kidney Dis. 2008;51(3):515-23.
17. Rich A, Ellershaw J, Ahmad R. Palliative care involvement in patients stopping haemodialysis. J. Palliative Med 2001; 15: 513-514.
18. Rhee CM, Kovesdy CP. Epidemiology: spotlight on CKD deaths-increasing mortality worldwide. Nat Rev Nephrol. 2015;11:199–20
19. Ajayi S, Salako BL. Unaffordability of renal replacement therapy in Nigeria. Hong Kong J Nephrol.2016; 15-19
20. KDOQI Clinical Practice Guidelines for Hemodialysis Adequacy: 2015 Update National Kidney Foundation. 2015: 66(5): 885-930 https://doi.org/10.1053/j.ajkd.2015.07.015
21. Halle MP, Ashuntantang G, Kaze FF, Takongue C, Kengne AP. Fatal outcomes among patients on maintenance haemodialysis in sub-Saharan Africa: a 10-year audit from the Douala General Hospital in Cameroon. BMC Nephrol. 2016; 3; 17(1):165. doi: 10.1186/s12882-016-0377-5.
22. Daugirdas JT. Second generation logarithmic estimates of single‐pool variable volume Kt/V: an analysis of error. J Am Soc Nephrol1993; 4:1205–1213
23.Avram MM, Mittman N, Fein PA, Agahiu S, Hartman W, Chattopadhyay N, Matza B. Dialysis vintage, body composition, and survival in peritoneal dialysis patients. Adv Perit Dial. 2012; 28:144-7.
24. Chattopadhyay T, Banerjee A, Mondal H. Causes of hospitalization in patients on maintenance hemodialysis with arteriovenous fistula in a tertiary care hospital in West Bengal, India. Saudi J Kidney Dis Transpl. 2021; 32(5):1418-1423. doi: 10.4103/1319-2442.344762.
25. Uduagbamen PK, Kadiri S. Intradialysis hypotension and hypertension in patients with end-stage kidney disease in Nigeria: risk factors
and clinical correlates. Ghana Med J. 2021; 55(1):34-42
26. Flythe JE, Curhan GC, Brunelli SM. Shorter length dialysis sessions are associated with increased mortality, independent of body weight. Kidney Int. 2013;83(1):104-13. doi: 10.1038/ki.2012.346..
27. Jurkovitz CT, Li S, Norris KC, Saab G, Bomback AS, Whaley-Connell AT, McCullough PA; KEEP Investigators. Association between lack of health insurance and risk of death and ESRD: results from the Kidney Early Evaluation Program (KEEP). Am J Kidney Dis. 2013; 61(4 Suppl
2):S24-32. doi: 10.1053/j.ajkd.2012.12.015
28. Wachterman MW, O’Hare AM, Rahman O, Lorenz KA, Marcantonio ER, Alicante GK, Kelley AS. One-Year Mortality After Dialysis Initiation Among Older Adults. JAMA Intern Med. 2019; 179(7):987–990. doi:10.1001/jamainternmed.2019.0125
29. Elsharif ME. Mortality rate of patients with end stage renal disease on regular hemodialysis: a single center study. Saudi J Kidney Dis Transpl. 2011; 22(3):594-6.
30. Ahmed M, Alalawi F, AlNour H, Gulzar K, Alhadari A. Five-Year Mortality Analysis in Hemodialysis Patients in a Single-Center in Dubai. Saudi J Kidney Dis Transpl. 2020; 31(5):1062-1068. doi: 10.4103/1319-2442.301172
31. Hyodo T, Yamashita AC, Hirawa N, Isaka Y, Nakamoto H, Shigematsu T. Present status of renal replacement therapy in lower-middle-income Asian countries: Cambodia, Myanmar, Laos, Vietnam, Mongolia, and Bhutan as of June 2019 (before COVID-19), from the interviews of leading doctors in every country: (duplicated English publication from "the special Japanese edition of educational lectures in the 64th annual meeting of the Japanese Society for Dialysis Therapy"). Ren Replace Ther. 2022;8(1):54. doi: 10.1186/s41100-022-00443-2.
32. Vietnam. From Wikipedia. https://en.wikipedia.org/wiki/Vietnam
33. Bhutan. From Wikipedia. https://en.wikipedia.org/wiki/Bhutan
34. Barra ABL, Silva APRD, Canziani MEF, Lugon JR, Matos JPS. Survival in hemodialysis in Brazil according to the source of payment for the treatment: Public Healthcare System (SUS) versus private insurance. J Bras Nefrol. 2023; 45(3):302-309. doi: 10.1590/2175-8239-JBN-2022-0131en.
35. Kassa DA, Mekonnen S, Kebede A, Haile TG. Cost of Hemodialysis Treatment and Associated Factors Among End-Stage Renal Disease Patients at the Tertiary Hospitals of Addis Ababa City and Amhara Region Ethiopia. Clinico econ Outcomes Res. 2020; 12:399-409
https://doi.org/10.2147/CEOR.S256947
36. Kalyesubula R, Brewster U, Kansiime G. Global Dialysis Perspective: Uganda. Kidney360. 2022 Mar 3;3(5):933-936. doi: 10.34067/KID.0007002021.
37. Bamikefa TA, Uduagbamen PK, Adelaja MA, Ala O. Demographic Pattern and Clinical Characteristics of Patients undergoing Haemodialysis in a Tertiary Centre of a Developing Country. A Review of 280 Cases. Ethiopian J Health Sci 2023; 30(6): 995-1004 doi: http://dx.doi.org/ 10.4314/ejhs. v33i6.10
38. Uduagbamen PK, Kadiri S. Dialysis prescription: Determinants and relationship with intradialytic complications and the dialysis dose. A prospective study. Ethiopian Med J 2023; 61(1): 51-60
39. Marin JG, Beresford L, Lo C, Pai A, Espino-Hernandez G, Beaulieu M. Prescription Patterns in Dialysis Patients: Differences Between Hemodialysis and Peritoneal Dialysis Patients and Opportunities for Deprescription. Can J Kidney Health Dis. 2020: 2054358120912652. doi: 10.1177/2054358120912652.
40. Kaze FF, Kengne AP, Choukem SP, Dzudie A, Halle MP, Dehayem MY, Ashuntantang G. Dialysis in Cameroon. Am J Kidney Dis. 2008 Jun;51(6):1072-4; author reply 1074. doi: 10.1053/j.ajkd.2008.02.366.
41. Wu BS, Wei CH, Yang CY, Lin MH, Hsu CC, Hsu YJ, Lin SH, Tarng DC. Mortality rate of end-stage kidney disease patients in Taiwan. J Formos Med Assoc. 2022; 121 Suppl 1:S12-S19. doi: 10.1016/j.jfma.2021.12.015.
42. Zhou M, Gu X, Cheng K, Wang Y, Zhang N. Exploration of symptom clusters during hemodialysis and symptom network analysis of older maintenance hemodialysis patients: a cross-sectional study. BMC Nephrol. 2023; 27; 24(1):115. doi: 10.1186/s12882-023-03176-4.
43. Bonenkamp AA, Hoekstra T, Hemmelder MH, Sluijs AE, Abrahams AC, van Ittersum FJ, et al. Trends in home dialysis use differ among age categories in past two decades: A Dutch registry study Eur J Clin Invest 2022; 52(1): e13656 https://doi.org/10.1111/eci.13656
44. Park JY, Yoo KD, Kim YC, Kim DK, Joo KW, Kang S-W, et al. Early dialysis initiation does not improve clinical outcomes in elderly end-stage renal disease patients: A multicenter prospective cohort study. PLoS ONE 2017; 12(4): e0175830. https://doi.org/10.1371/journal.pone.0175830
45. U.S. Renal Data System, 2021 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; Bethesda, MD, USA: 2021
