A Comparative Analysis of Laboratory Parameters of Hospitalized COVID-19 Patients by Disease Severity and Mortality at a Facility in Ibadan, Nigeria https://doi.org/10.60787/NMJ-64-2-188
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Keywords
SARS-CoV-2, COVID-19
Abstract
Background: COVID-19, which is caused by the SARS-CoV-2 virus, is associated with abnormalities of biochemical parameters. There are indications that some of these biochemical parameters can differ according to the severity of the disease and the outcome of the infection. This study describes and compares laboratory findings among COVID-19 patients hospitalized at a facility in Southwestern Nigeria according to disease severity and mortality.
Methodology: Records of 223 patients with COVID-19 disease admitted between March 2020 and May 2021 were retrospectively collected. Socio-demographic characteristics, laboratory parameters, and patient outcomes were obtained. Patients were classified according to COVID-19 severity. Laboratory parameters were compared between patients with severe and non-severe disease and between survivors and non-survivors.
Results: Of the 215 patients with some laboratory data included in the analysis, there were 133 (62%) males, and 56.7% were aged above 60 years. A total of 71.6% had severe COVID-19 and 48.4% died during hospitalization. The severe disease occurred significantly more frequently among non-survivors (P0.01). Higher leukocyte and neutrophil counts, urea levels, D-Dimer, and fasting blood glucose levels occurred significantly more frequently in both severe disease and mortality categories. Additionally, elevated GGT and CRP were significantly more common in those with severe than non-severe disease while lower haemoglobin, hematocrit, albumin, and higher creatinine levels were significantly more common in non-survivors.
Conclusion: Our study found that certain readily obtainable biochemical parameters occur more frequently with severe disease and/or mortality amongst patients hospitalized with COVID-19 in sub-Saharan Africa and might be useful for prognostication and allocation of resources.
References
2. Tessema SK, Nkengasong JN. Understanding COVID-19 in Africa. Nat Rev Immunol. 2021; 21:469–70.
3. Biamonte F, Botta C, Mazzitelli M, Rotundo S, Trecarichi EM, Foti D, et al. Combined lymphocyte/monocyte count, D-dimer and iron status predict COVID-19 course and outcome in a long-term care facility.J Transl Med. 2021;19:1–10.
4. Wolde M. Hematology, immunology and clinical chemistry profiles of COVID-19 patients: Systematic review. Ethiop J Heal Dev. 2020; 34:226–31.
5. Qin R, He L, Yang Z, Jia N, Chen R, Xie J, et al. Identification of Parameters Representative of Immune Dysfunction in Patients with Severe and Fatal COVID-19 Infection: a Systematic Review and Meta-analysis. Clinical Reviews in Allergy and Immunology. 2022.
6. Zhou F. Clinical Course And Risk Factors For Mortality Of Adult In Patients With COVID-19 In Wuhan, China: A Retrospective Cohort Study. J Med Study Res. 2020;3:01–2.
7. Henry B, Santos de Oliviera M, Benoit S, Plebani M, Lippi G. Hematological, biochemical and immune biomarker abnormalitie associted with severe ilness and mortality in coronavirsu disease (COVID-19): meya-analysis. Clin Chem Lab Med. 2020;10:0–4.
8. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506.
9. Guan W jie, Ni Z yi, Hu Y, Liang W hua, Ou C quan, He J xing, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382:1708–20.
10. Carpenter CR, Mudd PA, West CP, Wilber E, Wilber ST. Diagnosing COVID-19 in the Emergency Department: A Scoping Review of Clinical Examinations, Laboratory Tests, Imaging Accuracy, and Biases. Acad Emerg Med. 2020;27:653–70.
11. World Health Organisation. Clinical Management of sever acute respiratory infection (SARI) when COVID-19 disease is suspected. Interim Guidance. Geneva; 2020.
12. Bowale A, Abayomi A, Idris J, Omilabu S, Abdus-Salam I, Adebayo B, et al. Clinical presentation, case management and outcomes for the first 32 COVID-19 patients in Nigeria. Pan Afr Med J. 2020;35(Supp 2):24.
13. Abayomi A, Odukoya O, Osibogun A, Wright O, Adebayo B, Balogun M, et al. Presenting Symptoms and Predictors of Poor Outcomes Among Patients with COVID-19 in Lagos State, Nigeria.Int J Infect Dis. 2021;102:226–332.
14. Jibrin YB, Okwong OK, Maigari IM, Dunga JA, Ballah AM, Umar MS, et al. Clinical and laboratory characteristics of COVID-19 among adult patients admitted to the isolation centre at Abubakar Tafawa Balewa Teaching Hospital Bauchi, Northeast Nigeria. Pan Afr Med J. 2020;37(Supp 1):27.
15. Kantri A, Ziati J, Khalis M, Haoudar A, El Aidaoui K, Daoudi Y, et al. Hematological and biochemical abnormalities associated with severe forms of COVID-19: A retrospective single-center study from Morocco. PLoS One. 2021;16(2 February):1–10.
16. Li X, Xu S, Yu M, Wang K, Tao Y, Zhou Y et al. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J Allergy Clin Immunol. 2020;146:110–8.
17. Horiuchi Y, Hayashi F, Iwasaki Y, Matsuzaki A, Nishibe K, Kaniyu K, et al. Peripheral granular lymphocytopenia and dysmorphic leukocytosis as simple prognostic markers in COVID-19. Int J Lab Hematol. 2021;43:1309–18.
18. Arinola OG, Edem VF, Rahamon SK, Fowotade A, Onifade AA, Adekanmbi OB, et al. Haemocytometric Profile of Nigerian Patients with Covid-19 Haemocytometric Profile of Nigerian Patients with Covid-19. Arch Basic Appl Med. 2021;9(December):145–52.
19. Pujani M, Raychaudhuri S, Singh M, Kaur H, Agarwal S, Jain M, et al. An analysis of hematological, coagulation and biochemical markers in COVID-19 disease and their association with clinical severity and mortality: an Indian outlook. Am J Blood Res. 2021;11:580–91.
20. Ghweil AA, Hassan MH, Khodeary A, Mohamed AO, Mohammed HM, Abdelazez AA, et al. Characteristics, outcomes and indicators of severity for covid-19 amongsample of esna quarantine hospital’s patients, egypt: A retrospective study. Infect Drug Resist. 2020;13:2375–83.
21. Akter A, Ahmed T, Tauheed I, Akhtar M, Rahman SIA, Khaton F, et al. Disease characteristics and serological responses in patients withdiffering severity of COVID-19 infection: A longitudinal cohort study in Dhaka, Bangladesh. PLoS Negl Trop Dis. 2022;16:1–18.
22. Lippi G, Plebani M, Michael B. Thrombocytopenia in severe Covid cases. Clin Chim Acta. 2020;506(January):145–8.
23. Liu Y, Sun W, Guo Y, Chen L, Zhang L, Zhao S, et al. Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study. Platelets. 2020;31:490–6.
24. Bao C, Tao X, Cui W, Yi B, Pan T, Young KH, et al. SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients. Exp Hematol Oncol. 2020;9:1–8.
25. Iftikhar S, Ghias M, Shahid S, Ali MR, Hassan MU NA. Clinical and biochemical indicators of disease severity and neurological findings in COVID-19: A study of King Edward Medical University (KEMU), Pakistan. 2021;34(1(Supplementary). Pak J Pharm Sci. 2021; 34:275–81.
26. Alam JM, Asghar SS, Ali H, Mahmood SR AM. Profiling of inflammatory biomarkers in mild to critically ill severe acute respiratory syndrome corona virus-19 (SARS Covid-19) patients from Karachi, Pakistan. Pak J Pharm Sci. 2021;34:429–33.
27. Salık F, Uzundere O, Bıçak M, Akelma H, Akgündüz M, Korhan Zet al. Liver function as a predictor of mortality in COVID-19: A retrospective study. Ann Hepatol. 2021;26:100553.
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