Exploring diversity in Non-Alcoholic Fatty Liver Disease (NAFLD) among lean, overweight, and obese patients: A Multicenter study from India
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Keywords
Dyslipidemia, Diabetes, NAFLD, India, Diversity, Lean
Abstract
Background: One common chronic liver illness is non-alcoholic fatty liver disease (NAFLD) affecting individuals across various body weights. Traditionally associated with obesity, NAFLD is now increasingly observed in overweight and lean individuals as well. This research investigates the clinical, metabolic, dietary pattern, and socio-demographic differences of NAFLD in lean, overweight, and obese individuals across various centers in two Indian states.
Methodology: Conducted as a cross-sectional observational study with 154 NAFLD patients aged 18-65 years across four centers [Odisha (OD) -3; Uttar Pradesh (UP) -1], the research utilized a self-administered questionnaire to gather socio-economic, biochemical, and clinical data. Data analysis involved Chi-square tests at a 0.05 significance level. Trail Registration: CTRI/2024/04/065699.
Result: The majority of NAFLD cases were found in obese patients (37.01% in Odisha and 35.06% in UP). Overweight NAFLD was more common in UP (10.39%), while lean NAFLD was more prevalent in Odisha (7.14%). Obesity was significantly associated with diabetes in both states (p=0.020). Constipation was notable in overweight and obese groups (p=0.001 and p=0.027), and bloating was more frequent in overweight individuals (p=0.064). Loss of appetite was significant among lean NAFLD patients. Biochemical parameters and food consumption across ten food groups showed no significant variation.
Conclusion: Overall, NAFLD was more common among obese patients, highlighting the need for tailored dietary interventions based on body type.
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Dawesh Prakash Yadav, Department of Gastroenterology, Institute of Medical Sciences, Sir Sunderlal Hospital, Banaras Hindu University, Varanasi, India,
Professor and Head of the Department, Department of Gastroenterology, Institute of Medical Sciences, Sir Sunderalal Hospital, Banaras Hindu University, Varanasi, UP-221005, India,
Mukta Singh, Department of Home Science, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi, Uttar Pradesh, India,
Professor,Head of The Department,Department of Home Science,Mahila Mahavidyalaya, Banaras Hindu University, Varanasi, Uttar Pradesh- 221005, India
Dibyalochan Praharaj, Department of Gastroenterology and Hepatology, Kalinga Institute of Medical Sciences, KIIT Deemed to be University Bhubaneswar, Odisha, India,
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