Prevalence and Determinants of Singleton Stillbirths at a Tertiary Hospital in Port-Harcourt, Nigeria.
Main Article Content
Keywords
Stillbirth, Prevalence, Determinants, Perinatal mortality
Abstract
Background: Nigeria makes a substantial contribution to the global burden of stillbirths. Stillbirth accounts for about 50% of perinatal mortality and the stillbirth rate is an indicator of the quality of antenatal and intrapartum care. The study sought to determine the prevalence and determinants of stillbirths.
Methodology: This was a retrospective, unmatched case-control study over two years from May 2022 to April 2024. Cases were women with stillbirths that occurred at a gestational age of ≥28 weeks, while controls were women with livebirths, in a 1 case for 2 controls ratio. Data extracted from the hospital records, using a predesigned collection form, included demographic, medical, obstetric and neonatal characteristics as exposure variables. Data was analysed with SPSS version 25, using descriptive and inferential statistics. Multivariate logistics regression was used to determine adjusted odds ratios with 95% confidence intervals and a P-value of <0.05.
Results: There were 3,425 live births and 120 stillbirths, giving a stillbirth rate of 35 per 1000 live births. Analysis was performed for 114 cases and corresponding 228 controls, 6 cases were excluded for incomplete data. Maternal age ranged from 20-48 years and parity from 0-7, with no statistical difference between either group (P=0.982 and P=0.638 respectively). There were 58(50.9%) macerated and 56(49.1%) fresh stillbirths, with 21(37.5%) of the fresh stillbirths alive at presentation. Factors associated with stillbirth after multivariate analysis included unbooked status (aOR=9.64; P=0.0001), vaginal delivery (aOR=2.04; P=0.034), abruptio placenta (aOR=25.58; P=0.007), preterm delivery at GA ≤36 weeks (aOR=3.26; P=0.012), and low birth weight <2500g (aOR=3.53; P=0.016). Obstructed labour and ruptured uterus were significant in bivariate analysis but could not be fitted into multivariate analysis because of non-occurrence in controls.
Conclusion: The stillbirth rate at our Centre was 35 per 1000 live births. Associated factors for stillbirth were unbooked status, vaginal delivery, abruptio placenta, preterm delivery, and birth weight <2500g.
References
2. Barfield WD. Committee on Fetus and Newborn. Standard terminology for fetal, infant, and perinatal deaths. Pediatrics 2011; 128: 177-81.
3. Joseph KS, Liu S, Rouleau J, Lisinkova S, Hutcheon JA, Sauve R, et al. Influence of definition based versus pragmatic birth registration on international comparisons of perinatal and infant mortality: Population based retrospective study. BMJ 2012; 334: e746.
4. World Health Organization (WHO). International Statistical Classification of Diseases and Related Health Problems, 10th revision. 2nd ed. Geneva, Switzerland: WHO 2004.
5. World Health Organization (WHO). Stillbirths. In: Maternal, newborn, child and adolescent health [internet]. WHO 2017. Available from: http://www.who.int/maternal_child_adolescent/epidemiology/stillbirth/en/ Last accessed on Oct 31, 2017.
6. Lawn JE, Blencowe H, Pattinson R, Cousens S, Kumar R, Ibiebele I, et al. Stillbirths: Where? When? Why? How to make the data count? Lancet 2011; 377: 1448-63.
7. McClure EM, Nalubamba-Phiri M, Goldenberg RL. Stillbirth in developing countries. Int J Gynaecol Obstet 2006; 94: 82-90.
8. Obed SA. Intrauterine fetal death. In: Kwawukume EY, Emuveyan EE, editors. Comprehensive Obstetrics in the tropics. 1st ed. Accra, Asante and Hittscher Printing Press Ltd: 2002. p 193-7.
9. World Health Organization (WHO). Trends in maternal mortality: 1990 to 2015 [internet] WHO. 2015 Available from: http://www.who.int/reproductivehealth/publications/monitoring/maternal-mortality-2015/en/ Last accessed Oct 31, 2017.
10. Blencowe H, Cousens S, Jassir FB, Say L, Chou D, Mathers C, et al. National, regional, ana worldwide estimates of stillbirth rates in 2015, with trends from 2000: a systematic analysis. Lancet Glob Health. 2016; 4(2): e98-108.
11. Okonofua FE, Ntoimo LFC, Ogu R, Galadanci H, Mohammed G, Adetoye D, et al. Prevalence and determinants of stillbirth in Nigerian referral hospitals: a multicentre study. BMC Pregnancy and Childbirth. 2019; 19: 533 https://dx.doi.org/10.1186/s12884-019-2682-z
12. Lawn JE, Blencowe H, Waiswa P, Amouzou A, Mathers C, Hogan D, et al. Stillbirth rates, risk factors, and acceleration towards 2030. Lancet 2016; 387(10018): 587-603.
13. Okeudo C, Ezem B, Ojiyi E. Stillbirth rate in a teaching hospital in South-Eastern Nigeria: a silent tragedy. Ann Med Health Sci Res. 2012; 2(2): 176-9.
14. Onyiriuka AN. Analysis of stillbirths in a Nigerian mission hospital. Niger Q J Hosp Med. 2009; 19(1): 27-31.
15. Mutihir JT, Eka PO. Stillbirths at the Jos University teaching hospital: incidence hospital: incidence, risk, and etiological factors. Niger J Clin Pract. 2011; 14(1):14-8.
16. Suleiman BM, Ibrahim HM, Abdulkarim N. Determinants of Stillbirth in Katsina, Nigeria: A Hospital-Based Study. Pediatr Rep 2015 Mar 27;7(1):5615. doi: 10.4081/pr.2015.5615.
17. Feresu SA, Harlow SD, Welch K, Gillespie BW. Incidence of stillbirth and perinatal mortality and their associated factors among women delivering at Harare Maternity Hospital, Zimbabwe: a cross-sectional retrospective analysis. BMC Pregnancy and Childbirth 2005; 5: 9
18. Cnattingius S, Stephansson O. The epidemiology of stillbirth. Semin Perinatol 2002; 26: 25-30.
19. Audu BM, Alhaji MA, Takai UI, Bukar M. Risk factors for stillbirths at University of Maiduguri teaching hospital, Maiduguri, Nigeria: a cross-sectional retrospective analysis. Niger Med J. 2009; 50(2): 42
20. Njoku CO, Emechebe CI, Eyong EM, Ukaga JT, Anachuna KC. Prevalence and risk factors for stillbirths in a tertiary hospital in Niger Delta area of Nigeria: a ten-year review. Int J Med Biomed Res. 2016; 5(3): 106-13.
21. Cheong-See F, Schuit E, Arroyo-Manzano D, Khalil A, Barrett J, Joseph KS, et al. Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis. BMJ 2016; 354: i4353
22. McClure EM, Wright LL, Goldenberg RL, Goudar SS, Parida SN, Jehan I, et al. The global network: a prospective study of stillbirths in developing countries. Am J Obstet Gynecol. 2007; 197(3): 1-5. https://dx.doi.org/10.1016/j.ajog.2007.07.004
23. Shrestha SR, Yadav BK. Risk factors associated with stillbirths. J Nepal Med Assoc. 2010; 49(177): 84-7.
24. Jammeh A, Vangen S, Sundby J. Stillbirth in rural hospital in the Gambia: a cross-sectional retrospective study. Obstet Gynecol Int. 2010; 186867. https://dx.doi.org/10.1155/2010/186867
25. Cham M, Sundby J, Vangen S. Fetal outcome in severe maternal morbidity: too many stillbirths. Acta Obstet Gynecol Scand. 2009; 88(3): 343-9. https://dx.doi.org/10.1080/00016340902730318
26. Hossain N, Khan N, Khan NH. Obstetric causes of stillbirth at low socioeconomic settings. J Pak Med Assoc. 2009; 59(11): 744-7.
27. Onadeko MO, Lawoyin TO. The pattern of stillbirth in a secondary and a tertiary hospital in Ibadan, Nigeria. Afr J Med Sci. 2003; 32(4): 349-52.
28. Zupan J. Perinatal mortality in developed countries. N Engl J Med 2005; 352(20): 2047-8. https://dx.doi.org/10.1056/NEJMp058032
29. Goldenberg RL, McClure EM, Bann CM. The relationship of intrapartum and antepartum stillbirth rates to measures of obstetric care in developed and developing countries. Acta Obstet Gynecol Scand. 2007; 86: 13031309.
30. National Population Commission (NPC) [Nigeria] and ICF International. Nigeria Demographic and Health Survey 2013. Abuja, and Rockville: NPC and ICF International 2014.
31. Ugboma HAA, Onyearugha CN. Stillbirths in a tertiary hospital, Niger Delta area of Nigeria; less than a decade to the Millennium Development Goals. International Journal of TROPICAL DISEASE & Health. 2012; 2(1): 16-23.
32. Zile I, Ebela I, Rumba-Rozenfelde I. Maternal risk factors for stillbirths: A Registry-Based Study. Med (Mex). 2019; 55:326
33. Mforteh AA, Pisoh DW, Boten M, Andoh NE, Tameh TY, Mbi-Kobenge AE, et al. Stillbirth rate and associated factors at the Bamenda Regional hospital, North-West region, Cameroon, from 2018 to 2022: a case control study. BMC Pregnancy and Childbirth 2024; 24:270 https://dx.doi.org/10.1186/s12884-024-06486-z
34. Omo-Aghoja LO, Onohwakpor EA, Adeyinka AT, Omene JA. Incidence and Determinants of Stillbirth amongst Parturients in Two Hospitals in Southern Nigeria. Journal of Basic and Clinical Reproductive Sciences 2014; 3(1): 15-21.
35. Awoyesuku PA, Mac-Pepple DA, Altraide BO, John DH, Kwosah NJ. Pattern of Obstetric Clinic attendance, Deliveries and Neonatal outcome at a tertiary hospital during and after a Free Medical Care Programme. Journal of Advances in Medicine and Medical Research. 2020; 32(2): 22-31.
36. Okonta PI, Orimadegun AE, Umejiego C, Fajola A. An analysis of stillbirths from a busy Cottage hospital using the Re-Code classification. Tropical Journal of Obstetrics & Gynaecology. 2020; 37(2): 233-242.
37. Khadka D, Dhakal KB, Dhakal A, Rai SD. Stillbirths among pregnant women admitted to the department of obstetrics and gynaecology in a tertiary care centre: a descriptive cross-sectional study. J Nepal Med Assoc. 2022; 60:761-5.
38. Chuwa FS, Mwanamsangu AH, Brown BG, Msuya SE, Senkora EE, Mnali OP, et al. Maternal and fetal risk factors for stillbirth in Northern Tanzania: a registry-based retrospective cohort study. PLoS ONE. 2017; 12:e0182250.
39. Egbe TO, Ewane EN, Tendongfor N. Stillbirth rates and associated risk factors at the Buea and Limbe regional hospitals, Cameroon: a case-control study. BMC Pregnancy Childbirth 2020; 20:75
40. Mohammed-Ahmed A, Abdullahi A, Beshir F. Magnitude and associated factors of stillbirth among women who gave birth at Hiwot Fana Specialized University Hospital, Harar, eastern Ethiopia. Eur J Midwifery. 2022; 6:1-9.
41. Olusanya BO, Solanke OA. Predictors of term stillbirths in an inner-city maternity hospital in Lagos, Nigeria. Acta Obstet Gynecol Scand 2009; 88:1243-51.
42. Ukaegbe U, Nwogu-Ikojo E, Ezegwui HU. Stillbirths at a tertiary medical Centre in Enugu, Nigeria. Trop J Med Res 2012; 15:1-4.
43. Kuti O, Owolabi AT, Orji EO, Ogunlola IO. Antepartum foetal death in a Nigerian Teaching Hospital: aetiology and risk factors. Trop J Obstet Gynaecol 2003; 20:134-6.
44. Avachat SS, Phalke DB, Phalke VD. Risk factors associated with stillbirths in the rural area of Western Maharashtra, India. Arch Med Health Sci. 2015; 3:56
45. Millogo T, Ouedraogo GH, Baguiya A, Meda IB, Kouanda S, Sondo B. Factors associated with fresh stillbirths: a hospital-based, matched, case-control study in Burkina Faso. Int J Gynecol Obstet. 2016; 135:S98-102.
46. Aminu M, Unkels R, Mdegela M, Utz B, Adaji S, van den Broek N. Causes of and factors associated with stillbirth in low- and middle-income countries: a systematic literature review. BJOG 2014; 121(suppl 4):141-53.
47. Shyam P. Analysis of risk factors for stillbirth: a hospital-based study in a tertiary care centre. Int J Reprod Contracept Obstet Gynecol. 2016; 5:525-30.
48. Engel PJ, Smith R, Brinsmead MW, Bowel SJ, Clifton VL. Male sex and pre-existing diabetes are independent risk factors for stillbirth. Aust N Z J Obstet Gynaecol 2008; 48:375-83.
49. Mondel D, Galloway TS, Bailey T, Mathew F. Elevated risk of stillbirth in males: systematic review and meta-analysis of more than 30 million births. BMC Medicine 2014;12:220.