Severe Respiratory Acidosis-induced Involuntary Hyper defecation: The Role of Medullary Caudal Raphe Nuclei

Main Article Content

Ankur Khandelwal
Department of Anaesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences (AIIMS), Guwahati Silbharal, Changsari, Assam, India
https://orcid.org/0000-0002-7915-9158
Priyadarshi Dikshit
Department of Anaesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences (AIIMS), Guwahati Silbharal, Changsari, Assam, India.
https://orcid.org/0000-0003-4811-4392
Pankaj Deori
Department of Anaesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences (AIIMS), Guwahati Silbharal, Changsari, Assam, India.
https://orcid.org/0009-0002-7863-6490
Dalim Kumar Baidya
Department of Anaesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences (AIIMS), Guwahati Silbharal, Changsari, Assam, India.
https://orcid.org/0000-0001-7811-7039

Keywords

Respiratory Acidosis, Involuntary Hyper defecation, Medullary Caudal Raphe Nuclei

Abstract

This correspondence reports a case of a 9-year-old male child with progressive quadriparesis from congenital atlantoaxial dislocation with respiratory depression secondary to the compression of the cervical-medullary junction and spinal cord oedema. The child developed severe respiratory acidosis and subsequent involuntary hyper-defecation. This correspondence explores the role of the medullary caudal raphe nuclei in the pathogenesis of severe Respiratory Acidosis-induced involuntary hyper defecation.

Abstract 64 | PDF Downloads 66 EPUB Downloads 7

References

1. Heitmann PT, Vollebregt PF, Knowles CH, Lunniss PJ, Dinning PG, Scott SM. Understanding the physiology of human defaecation and disorders of continence and evacuation. Nat Rev Gastroenterol Hepatol. 2021;18(11):751-769. doi: 10.1038/s41575-021-00487-5.

2. Takaki M, Neya T, Nakayama S. Pelvic afferent reflex control of rectal motility and lumbar colonic efferent discharge mediated by the pontine sympatho-inhibitory region in guinea pigs. Pflugers Arch. 1985;403(2):164-9. doi: 10.1007/BF00584095.

3. Nakamori H, Naitou K, Horii Y, Shimaoka H, Horii K, Sakai H, et al. Medullary raphe nuclei activate the lumbosacral defecation center through the descending serotonergic pathway to regulate colorectal motility in rats. Am J Physiol Gastrointest Liver Physiol. 2018;314(3): G341-G348. doi: 10.1152/ajpgi.00317.2017.

4. Richerson GB. Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis. Nat Rev Neurosci. 2004;5(6):449-61. doi: 10.1038/nrn1409.

5. Corcoran AE, Hodges MR, Wu Y, Wang W, Wylie CJ, Deneris ES, et al. Medullary serotonin neurons and central CO2 chemoreception. Respir Physiol Neurobiol. 2009;168(1-2):49-58. doi: 10.1016/j.resp.2009.04.014.

Article Sidebar

PDF EPUB
Published
Jan 10, 2025
DOI https://doi.org/10.60787/nmj.v65i6.665

Article Details

How to Cite
Khandelwal, A., Dikshit, P., Deori, P., & Baidya, D. K. (2025). Severe Respiratory Acidosis-induced Involuntary Hyper defecation: The Role of Medullary Caudal Raphe Nuclei. Nigerian Medical Journal, 65(6), 1194–1196. https://doi.org/10.60787/nmj.v65i6.665
Issue
Vol. 65 No. 6 (2024): November to December
Section
Letter to the Editor
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This is an open-access journal and articles are distributed under the terms of the Creative Commons Attribution Non-Commercial Share-Alike License 4.0. This licence allows users to download and share, remix, tweak and build upon the article for non-commercial purposes, so long as the original authorship is acknowledged and the new creations are licensed under identical terms.

Author Biographies

Priyadarshi Dikshit, Department of Anaesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences (AIIMS), Guwahati Silbharal, Changsari, Assam, India.

 

 

Pankaj Deori, Department of Anaesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences (AIIMS), Guwahati Silbharal, Changsari, Assam, India.